{"id":4976,"date":"2016-05-25T22:42:32","date_gmt":"2016-05-26T02:42:32","guid":{"rendered":"http:\/\/www.khpi.org\/blog\/?p=4976"},"modified":"2016-05-25T22:48:44","modified_gmt":"2016-05-26T02:48:44","slug":"update-on-the-rising-prices-of-insulin-between-2013-and-2016","status":"publish","type":"post","link":"http:\/\/www.khpi.org\/blog\/update-on-the-rising-prices-of-insulin-between-2013-and-2016\/","title":{"rendered":"Update On The Rising Prices of Insulin Between 2013 and 2016."},"content":{"rendered":"<p>Earlier this month I published a survey of the <a href=\"http:\/\/www.khpi.org\/blog\/soaring-insulin-prices-highlight-broken-pharmaceutical-policy\/\" target=\"_blank\">cost of insulin<\/a> to the Medicaid and Medicare programs of Kentucky and the nation. \u00a0Fully 9.1% of the total cost of Kentucky\u2019s outpatient Medicaid drug program went to pay for the several brands of Insulin still available. It was obvious that some brands cost a lot more per prescription or claim than others and that the most expensive brands were prescribed most often!\u00a0 I used this critically important drug as an example of how the market for prescription drugs in America is badly broken.\u00a0 Since then I stumbled on two additional <a href=\"https:\/\/www.medicaid.gov\/Medicaid-CHIP-Program-Information\/By-Topics\/Benefits\/Prescription-Drugs\/Survey-of-Retail-Prices.html\" target=\"_blank\">federal databases<\/a> that provide additional insight into how much these drugs cost\u00a0at the local pharmacy counter where the rubber hits the road. These are federal surveys that determine the National Average Retail Prices paid by the consumer (NARP), and the National Average Drug Acquisition Cost (NADAC) for\u00a0the pharmacy.\u00a0 Both these programs provide data at the cost per milliliter level, and otherwise facilitate apple-to-apple comparisons of the different brands.\u00a0 In brief, the additional data confirm that in 2013, for the same size bottle, the newer insulin analogs cost 71% more than the older \u201chuman\u201d insulins. \u00a0By 2015, all prices had increased; some substantially.\u00a0 Valuable information about the retail prices of drugs is being kept from public inspection.<!--more--><\/p>\n<p>At the time I wrote the article, I was still blundering about in the deliberate darkness that surrounds what people actually pay for their drugs. \u00a0If you are like me, you have absolutely no confidence that either the full or discounted prices printed on our receipts from the drugstore have any basis in reality. \u00a0We are led to believe that our insurer has obtained big discounts for us and that we should be grateful we do not have to pay even more than we do.\u00a0 Of course, without knowledge of what the drug maker charges its distributers, how much the pharmacy benefit managers collect and pay, the acquisition cost of the drugs to the pharmacy, the amounts of any rebates or other incentives, or even how much the insurer really shells out; it is impossible to know if anybody is making an effort to protect our interests as patients.\u00a0 Too many entities are feeding at the same trough.<\/p>\n<p><strong>National Average Retail Prices.<\/strong><br \/>\nBack in 2012, CMS, the agency that administers Medicare and Medicaid, began a program to determine just how much money was crossing the retail counter of chain and independent pharmacies. Information was collected directly from the pharmacies including payer, quantity dispensed, and price.\u00a0 This latter included the combined prices paid for drug ingredient costs, customer pay amounts, and dispensing fees. Alas, Congress killed the program before we the people could benefit from the results, but not before data for at least part of 2013 was collected and posted as a \u201cdraft\u201d on the CMS website along with information about methodology.\u00a0 [Is there any doubt about whose interests were being protected by Congress? No doubt this represented another triumph of lobbying by industry.]<\/p>\n<p>Below is a table of NARP for insulin products in 2013. From the complete list I abstracted all vials containing the industry standard of 10 milliliters (ML) of insulin at a concentration of 100 units per ML.\u00a0 Prices are given per ML for Fee-for-Service <u>Medicaid<\/u>, <u>Third Party<\/u> payers including Medicaid and Medicare managed care and other insurers, and <u>Cash<\/u> payers that would include the indigent and uninsured. A national weighted average of these is designated as the NARP [per ML].\u00a0 The cost of the most commonly dispensed 10 ML vial can be calculated.<\/p>\n<p><a href=\"http:\/\/www.khpi.org\/blog\/wp-content\/uploads\/2016\/05\/narp-insulin-2013-table.png\" target=\"_blank\" rel=\"attachment wp-att-4978\"><img loading=\"lazy\" class=\"aligncenter wp-image-4978 size-full\" src=\"http:\/\/www.khpi.org\/blog\/wp-content\/uploads\/2016\/05\/narp-insulin-2013-table.png\" alt=\"narp-insulin-2013-table\" width=\"724\" height=\"800\" srcset=\"http:\/\/www.khpi.org\/blog\/wp-content\/uploads\/2016\/05\/narp-insulin-2013-table.png 724w, http:\/\/www.khpi.org\/blog\/wp-content\/uploads\/2016\/05\/narp-insulin-2013-table-136x150.png 136w, http:\/\/www.khpi.org\/blog\/wp-content\/uploads\/2016\/05\/narp-insulin-2013-table-272x300.png 272w, http:\/\/www.khpi.org\/blog\/wp-content\/uploads\/2016\/05\/narp-insulin-2013-table-575x635.png 575w\" sizes=\"(max-width: 709px) 85vw, (max-width: 909px) 67vw, (max-width: 984px) 61vw, (max-width: 1362px) 45vw, 600px\" \/><\/a><\/p>\n<p><strong>Results<\/strong>.<br \/>\nThe older brands of human insulin (Humulin and Novolin) cost $79-80 per vial in 2013. The average prices of the five insulin analog brands was $135 which was 71% higher than the older human insulins. Are the newer insulins worth the money?\u00a0 What do they do that the old standards cannot? I do not know the answers but I am confident that we could all share in some savings. \u00a0Here is an external link to the\u00a0<a href=\"https:\/\/public.tableau.com\/views\/AverageRetailPricesforInsulin2013\/10MLVials?:embed=y&amp;:display_count=yes&amp;:showTabs=y\" target=\"_blank\">graphic visualization<\/a> of the NARP data appearing below.<\/p>\n<p><script src=\"https:\/\/public.tableau.com\/javascripts\/api\/viz_v1.js\" type=\"text\/javascript\"><\/script><\/p>\n<div class=\"tableauPlaceholder\" style=\"width: 982px; height: 745px;\"><noscript>&amp;lt;a href=&#8217;#&#8217;&amp;gt;&amp;lt;img alt=&#8217; &#8216; src=&#8217;https:&amp;amp;#47;&amp;amp;#47;public.tableau.com&amp;amp;#47;static&amp;amp;#47;images&amp;amp;#47;Av&amp;amp;#47;AverageRetailPricesforInsulin2013&amp;amp;#47;10MLVials&amp;amp;#47;1_rss.png&#8217; style=&#8217;border: none&#8217; \/&amp;gt;&amp;lt;\/a&amp;gt;<\/noscript><object class=\"tableauViz\" style=\"display: none;\" width=\"982\" height=\"745\"><param name=\"host_url\" value=\"https%3A%2F%2Fpublic.tableau.com%2F\" \/><param name=\"site_root\" value=\"\" \/><param name=\"name\" value=\"AverageRetailPricesforInsulin2013\/10MLVials\" \/><param name=\"tabs\" value=\"yes\" \/><param name=\"toolbar\" value=\"yes\" \/><param name=\"static_image\" value=\"https:\/\/public.tableau.com\/static\/images\/Av\/AverageRetailPricesforInsulin2013\/10MLVials\/1.png\" \/><param name=\"animate_transition\" value=\"yes\" \/><param name=\"display_static_image\" value=\"yes\" \/><param name=\"display_spinner\" value=\"yes\" \/><param name=\"display_overlay\" value=\"yes\" \/><param name=\"display_count\" value=\"yes\" \/><param name=\"showTabs\" value=\"y\" \/><\/object><\/div>\n<p>&nbsp;<\/p>\n<p><strong>How much for convenience?<\/strong><br \/>\nPre-mixes of short and long acting insulin were uniformly more expensive than multi-dose vials of a single type. For at least some patients, the mixtures would simplify drawing up their doses or perhaps even eliminating the need for one or more additional injections.\u00a0 On the other hand, the fixed proportions of short and long acting insulin might not always be the best for a given person or situation.<\/p>\n<p>It is obvious that insulin prepared in self-injecting \u201cpens\u201d or replacement 15 ml cartridges is more expensive than multi-dose vials.\u00a0 Refill cartridges by themselves were some 22% more expensive per ML than multi-dose vials.\u00a0 I do not know how to adjust for the cost of the injector or syringes in these comparisons, but there is a substantial cost for the convenience of not having to use single-use insulin syringes.\u00a0 There is no question though, that for some individuals with impaired vision, judgement, or manual dexterity, that the self-injecting pens or pre-filled syringes can easily be justified.\u00a0 Should they be paid to anyone on demand out of pooled premium or tax dollars?\u00a0 I predict there would be many answers to that question! \u00a0I do not offer one here but in a world of limited resources it is ethical to say no.<\/p>\n<p>I do not have a good idea how long a single 10 ML vial containing 1000 units would last for a typical diabetic.\u00a0 Hypothetically, if a 160 lb. person required 40 units of insulin per day, a 10 ml vial of a single type would last for 25 days requiring some 15 vials per year.\u00a0 For Novolin this would in 2013 have cost $1,185 and for Lantus, $2,055. [I welcome a more knowledgeable calculation!]<\/p>\n<p><strong>Other thoughts about the data.<\/strong><br \/>\nI was quite surprised that there was not much difference in retail prices between Fee-for-Service Medicaid, managed care, or even cash! Cash payers paid more as would be predicted\u2013 but not as much as I expected.\u00a0 Medicaid is supposed to get \u201cbest prices\u201d with substantial rebates on covered drugs used in its programs.\u00a0 I have to believe the amount of any rebate is not reflected in these retail prices. Such are the enduring mysteries of drug pricing that I must leave it at that.<\/p>\n<p><strong>National Average Drug Acquisition Cost.<\/strong><br \/>\nUnlike the Average Retail Price initiative which was begun at about the same time, this CMS program has endured.\u00a0 As I understand it replaces the unreliable \u201cAverage Wholesale Price\u201d system that was subject to abuse.\u00a0 The purpose of the NADAC is to provide state Medicaid programs with the ingredient cost to a pharmacy so as to inform state negotiations with pharmacies, benefit managers, and other dispensers of drugs. These costs are derived from a sample of chain and independent pharmacies and refreshed at monthly intervals if not more frequently. The NADAC describes the cost of the active ingredient in a given drug and does not include \u00a0dispensing fees or costs of transport or storage.\u00a0 A fair amount of detail is provided in the database including comparisons with prices of generic or similar drugs when relevant.\u00a0 Of course, in the case of insulin, no generics are available for comparison. Below are selected NADAC data for insulins as of April 2016. As was the case for Average Retail Prices, the NADAC prices are much lower than I was able to calculate from Medicare and Medicaid utilization data and I do not yet know what to make of the differences. An external interactive data visualization is <a href=\"https:\/\/public.tableau.com\/views\/InsulinDrugAcquisitionCost-April2016\/AllInsulins?:embed=y&amp;:display_count=yes&amp;:showTabs=y\" target=\"_blank\">available here<\/a>.<\/p>\n<p><a href=\"http:\/\/www.khpi.org\/blog\/wp-content\/uploads\/2016\/05\/nadac-insulin100-vials-apr2016.jpg\" rel=\"attachment wp-att-4985\"><img loading=\"lazy\" class=\"aligncenter size-full wp-image-4985\" src=\"http:\/\/www.khpi.org\/blog\/wp-content\/uploads\/2016\/05\/nadac-insulin100-vials-apr2016.jpg\" alt=\"nadac-insulin100-vials-apr2016\" width=\"786\" height=\"438\" srcset=\"http:\/\/www.khpi.org\/blog\/wp-content\/uploads\/2016\/05\/nadac-insulin100-vials-apr2016.jpg 786w, http:\/\/www.khpi.org\/blog\/wp-content\/uploads\/2016\/05\/nadac-insulin100-vials-apr2016-150x84.jpg 150w, http:\/\/www.khpi.org\/blog\/wp-content\/uploads\/2016\/05\/nadac-insulin100-vials-apr2016-300x167.jpg 300w, http:\/\/www.khpi.org\/blog\/wp-content\/uploads\/2016\/05\/nadac-insulin100-vials-apr2016-768x428.jpg 768w, http:\/\/www.khpi.org\/blog\/wp-content\/uploads\/2016\/05\/nadac-insulin100-vials-apr2016-575x320.jpg 575w\" sizes=\"(max-width: 709px) 85vw, (max-width: 909px) 67vw, (max-width: 984px) 61vw, (max-width: 1362px) 45vw, 600px\" \/><\/a><\/p>\n<p><strong>Comparison with National Average Retail Price of 2013.<br \/>\n<\/strong>If the data is valid and I have interpreted the two datasets correctly, it is apparent that the prices of all the insulin products has risen, and in some cases, substantially.\u00a0 Recall that retail prices in 2016 will be considerably higher than specified by their drug acquisition cost that does not include non-ingredient costs to the pharmacy nor a profit margin. Nonetheless, even with these incomplete apples to oranges comparisons, the rises in costs in just 3 years are impressive.\u00a0 Humalog 100 numbers changed the most from $14.51 per ml. to $45.53.\u00a0 Lantus 100 went from $13.74 per ml to $24.03 but this reflects a price drop last year. The remaining insulin analogs were also in the range of $23 to $26 per ml.\u00a0 Humulin 100, a formerly modestly priced human insulin, more than tripled from $7.99 to $25.0 to join its upscale analog cousins. The human insulin Novolin 100 (and its Walgreen-branded version, Relion Novolin 100) remains the least expensive insulin available in the US with an average retail cost in 2013 of $7.88 rising to an average acquisition cost in 2016 of $12.47 for both rapid and slow acting versions and even for its short\/long acting mix!<\/p>\n<p>My hat is off to Novo Nordisk, Inc., the Danish multinational company that makes the Novolin family of human insulins, for keeping these prices lower.\u00a0 I leave it to Novo Nordisk to justify why its Novolog brand of insulin analog is so much more expensive.\u00a0 I leave it to my colleagues in general medical practice and endocrinology to explain why the least expensive Novolin is not appropriate and used more for all diabetics!\u00a0 Having offered this challenge, I grant that there will be good reasons to have the larger armamentarium available but I doubt that exceptions to the rule of \u201cuse the least expensive effective drug first\u201d will justify the insulin prescribing profiles in Medicare and Medicaid that initiated this series of articles. Surely we can more efficiently distribute resources in the interests of our diabetic patients and neighbors. None of this is possible however without more transparency in what our drugs cost.\u00a0 We maneuver today in deliberate confusion that cannot be justified.<\/p>\n<p>As always and especially in the realm of drug prices, it is possible I have misinterpreted some of the data or made other errors.\u00a0 Help me correct these. \u00a0What can be learned from consideration of how insulin is prescribed will apply to other drugs and many other medical services. What other families of drugs should I look at?<\/p>\n<p>Peter Hasselbacher, MD<br \/>\nPresident, KHPI<br \/>\nEmeritus Professor of Medicine, UofL<br \/>\n25 May 2016<\/p>\n<p>&nbsp;<\/p>\n<div class=\"sharedaddy sd-sharing-enabled\"><div class=\"robots-nocontent sd-block sd-social sd-social-icon-text sd-sharing\"><h3 class=\"sd-title\">Share this:<\/h3><div class=\"sd-content\"><ul><li><a href=\"#\" class=\"sharing-anchor sd-button share-more\"><span>Share<\/span><\/a><\/li><li class=\"share-end\"><\/li><\/ul><div class=\"sharing-hidden\"><div class=\"inner\" style=\"display: none;\"><ul><li class=\"share-facebook\"><a rel=\"nofollow noopener noreferrer\" data-shared=\"sharing-facebook-4976\" class=\"share-facebook sd-button share-icon\" href=\"http:\/\/www.khpi.org\/blog\/update-on-the-rising-prices-of-insulin-between-2013-and-2016\/?share=facebook\" target=\"_blank\" title=\"Click to share on Facebook\" ><span>Facebook<\/span><\/a><\/li><li class=\"share-linkedin\"><a rel=\"nofollow noopener noreferrer\" data-shared=\"sharing-linkedin-4976\" class=\"share-linkedin sd-button share-icon\" href=\"http:\/\/www.khpi.org\/blog\/update-on-the-rising-prices-of-insulin-between-2013-and-2016\/?share=linkedin\" target=\"_blank\" title=\"Click to share on LinkedIn\" ><span>LinkedIn<\/span><\/a><\/li><li class=\"share-end\"><\/li><li class=\"share-twitter\"><a rel=\"nofollow noopener noreferrer\" data-shared=\"sharing-twitter-4976\" class=\"share-twitter sd-button share-icon\" href=\"http:\/\/www.khpi.org\/blog\/update-on-the-rising-prices-of-insulin-between-2013-and-2016\/?share=twitter\" target=\"_blank\" title=\"Click to share on Twitter\" ><span>Twitter<\/span><\/a><\/li><li class=\"share-email\"><a rel=\"nofollow noopener noreferrer\" data-shared=\"\" class=\"share-email sd-button share-icon\" href=\"mailto:?subject=%5BShared%20Post%5D%20Update%20On%20The%20Rising%20Prices%20of%20Insulin%20Between%202013%20and%202016.&body=http%3A%2F%2Fwww.khpi.org%2Fblog%2Fupdate-on-the-rising-prices-of-insulin-between-2013-and-2016%2F&share=email\" target=\"_blank\" title=\"Click to email a link to a friend\" data-email-share-error-title=\"Do you have email set up?\" data-email-share-error-text=\"If you&#039;re having problems sharing via email, you might not have email set up for your browser. You may need to create a new email yourself.\" data-email-share-nonce=\"8bd7561796\" data-email-share-track-url=\"http:\/\/www.khpi.org\/blog\/update-on-the-rising-prices-of-insulin-between-2013-and-2016\/?share=email\"><span>Email<\/span><\/a><\/li><li class=\"share-end\"><\/li><li class=\"share-end\"><\/li><\/ul><\/div><\/div><\/div><\/div><\/div>","protected":false},"excerpt":{"rendered":"<p>Earlier this month I published a survey of the cost of insulin to the Medicaid and Medicare programs of Kentucky and the nation. \u00a0Fully 9.1% of the total cost of Kentucky\u2019s outpatient Medicaid drug program went to pay for the several brands of Insulin still available. It was obvious that some brands cost a lot &hellip; <a href=\"http:\/\/www.khpi.org\/blog\/update-on-the-rising-prices-of-insulin-between-2013-and-2016\/\" class=\"more-link\">Continue reading<span class=\"screen-reader-text\"> &#8220;Update On The Rising Prices of Insulin Between 2013 and 2016.&#8221;<\/span><\/a><\/p>\n<div class=\"sharedaddy sd-sharing-enabled\"><div class=\"robots-nocontent sd-block sd-social sd-social-icon-text sd-sharing\"><h3 class=\"sd-title\">Share this:<\/h3><div class=\"sd-content\"><ul><li><a href=\"#\" class=\"sharing-anchor sd-button share-more\"><span>Share<\/span><\/a><\/li><li class=\"share-end\"><\/li><\/ul><div class=\"sharing-hidden\"><div class=\"inner\" style=\"display: none;\"><ul><li class=\"share-facebook\"><a rel=\"nofollow noopener noreferrer\" data-shared=\"sharing-facebook-4976\" class=\"share-facebook sd-button share-icon\" href=\"http:\/\/www.khpi.org\/blog\/update-on-the-rising-prices-of-insulin-between-2013-and-2016\/?share=facebook\" target=\"_blank\" title=\"Click to share on Facebook\" ><span>Facebook<\/span><\/a><\/li><li class=\"share-linkedin\"><a rel=\"nofollow noopener noreferrer\" data-shared=\"sharing-linkedin-4976\" class=\"share-linkedin sd-button share-icon\" href=\"http:\/\/www.khpi.org\/blog\/update-on-the-rising-prices-of-insulin-between-2013-and-2016\/?share=linkedin\" target=\"_blank\" title=\"Click to share on LinkedIn\" ><span>LinkedIn<\/span><\/a><\/li><li class=\"share-end\"><\/li><li class=\"share-twitter\"><a rel=\"nofollow noopener noreferrer\" data-shared=\"sharing-twitter-4976\" class=\"share-twitter sd-button share-icon\" href=\"http:\/\/www.khpi.org\/blog\/update-on-the-rising-prices-of-insulin-between-2013-and-2016\/?share=twitter\" target=\"_blank\" title=\"Click to share on Twitter\" ><span>Twitter<\/span><\/a><\/li><li class=\"share-email\"><a rel=\"nofollow noopener noreferrer\" data-shared=\"\" class=\"share-email sd-button share-icon\" href=\"mailto:?subject=%5BShared%20Post%5D%20Update%20On%20The%20Rising%20Prices%20of%20Insulin%20Between%202013%20and%202016.&body=http%3A%2F%2Fwww.khpi.org%2Fblog%2Fupdate-on-the-rising-prices-of-insulin-between-2013-and-2016%2F&share=email\" target=\"_blank\" title=\"Click to email a link to a friend\" data-email-share-error-title=\"Do you have email set up?\" data-email-share-error-text=\"If you&#039;re having problems sharing via email, you might not have email set up for your browser. 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